How to reduce sample size without losing power in clinical trials?
Reducing sample size without losing power can be accomplished in one of three principles.
- Improve the signal-to-noise ratio. To do this, you can either reduce the noise, strengthen the signal, or reduce variability (which will both reduce the noise and strengthen the signal).
- Use a better statistical technique. By doing this you may be able to extract more information out of your data.
- Multiplex. On a basic level this involves using the the same patient more than once.
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