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Step 1:
Select the Group Sequential Test of Two Survivals with Accrual (STT15) table from the Study Design Pane.
This can be done using the radio buttons or alternatively, you can use the search bar at the end of the Select Test Design & Goal window.
Step 2:
From the Assistants menu select Survival Parameter Converter.
Convert the median survival time and hazard ratio into ‘’Group Exponential Parameter".
Step 3:
Back in table STT15, enter the values for sample size calculation taken from the study design statement.
At the bottom of the table, be sure to change the Number of Looks from the default to “2”. This specifies one interim analysis and one endpoint analysis.
Step 4:
Now enter the power 95% and click Run.
The sample size and number of events will auto calculate.
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Step 5:
nQuery Advanced also provides graphs. The sample size and number of events will auto calculate. To access plots, go to the menu and select Plot > Your graph
Step 6:
Calculate the sample size adjusted for expected 10% dropout
| This gives a final sample size of 414 per group as per study design statement |
