An open portfolio of interoperable, industry leading products
The Dotmatics digital science platform provides the first true end-to-end solution for scientific R&D, combining an enterprise data platform with the most widely used applications for data analysis, biologics, flow cytometry, chemicals innovation, and more.
Step 1:
Select the table Compute Power or Sample Size for Two-Sample Chi-Squared Test from the Select Test Design & Goal window.
This is located under the Chi-Squared Test to Compare Two Proportions dropdown.
This can be done using the radio buttons or alternatively, you can use the search bar at the end of the Select Test Design & Goal window.
Step 2:
Enter the parameter values for power calculation taken from the study protocol.
Enter the sample size of 52 per group as per study design.
Select calculate the power from the dropdown menu.
Step 3:
With the Sample Size per Group entered, select Calculate the power from the dropdown menu and click Run.
| This gives 80% power, as per the study design |
Step 4:
Once the calculation is completed, nQuery Advanced provides an output statement summarizing the results. It States:
| Output Statement: |
|
“A two group χ² test with a 5% two-sided significance level will have 82.57% power to detect the difference between a Group 1 proportion, π₁, of 0.23 and a Group 2 proportion, π₂ of 0.5 (odds ratio of 3.348) when the sample size in each group is 52.” |
