More about the webinar
Parametric tests are commonly used in clinical trials in order to examine candidate treatments. However, these tests require that the underlying data satisfies certain assumptions.
For example, common methods such as t-tests and ANOVA are optimal when the data is continuous and normally distributed. In the cases where distributional or other assumptions are not met then semi-parametric and non-parametric tests may be useful.
Semi-parametric methods such as Cox Regression for survival data or proportional odds models and non-parametric tests such as Mann-Whitney U tests and quantile regression are therefore an essential tool for statistical analysis.
Common scenarios where non-parametric tests are useful are for ordinal (e.g. pain severity scales) and interval (e.g. Likert scales) data, where the outcome data has an order but is not continuous, and for complex continuous data such as when comparing data from fat-tailed distributions.
Given the wide range of scenarios considered for non-parametric tests, there is also a wide range of sample size methods available for finding the appropriate size for a trial. These methods can allow researchers to better explore the implications of their trial outcome on study power and feasibility.
In this free webinar, we cover non-parametric tests, non-parametric equivalents to popular parametric tests and practical examples of sample size determination for a selection of non-parametric tests including the Wilcoxon signed-rank test and the Wilcoxon-Mann-Whitney U tests for both continuous and ordinal outcomes.
