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On-Demand Webinars
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Free recorded webinars from the development and support team on a wide variety of sample size topics.

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User Manuals
Documents all new and exiting features


Browse our user manuals nQuery Advisor + nTerim which document the features in new and older versions.

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Validation procedures and reports


Learn more about the methods we use for testing here. Get more details of the validation reports for sample size

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Comparison Docs
Upgrade comparison list


Free upgrade comparison list detailing newest features, utilities, sample size tables & plots.

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White Paper
Free white paper download


Why perform a power or sample size calculation in a study’s design? Learn how and why in 6 easy steps.

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What’s New in nQuery Advisor + nTerim 4.0


Check in to see the latest sample size tables in nQuery Advisor 4.0

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Americal Journal of Physiology – Gastroenterology – Means

Effects of a Selective Chloride Channel Activator, Lubiprostone, on Gastrointestinal Transit, Gastric Sensory, and Motor Functions in Healthy Volunteers

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Clinical Research and Regulatory Affairs – Gynecology – Higher Order Crossover

Single Dose Pharmacokinetics and Bioequivalence of Conjugated Estrogens (0.625 mg x 2) Tablets in Healthy Post-Menopausal Female Subjects in Fasting and Fed Studies 

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AAC – Respiratory – Higher Order Crossover

Safety, Tolerability, and Pharmacokinetics of Intravenous Oseltamivir: Single- and Multiple- Dose Phase I Studies with Healthy Volunteers 

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Acta Odontologica Scandinavica – Orthodontology – Means

Risk Profile and Quality of Dental Restorations: A Cross-Sectional Study 

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International Journal of Public Health – General Practice – Cluster Randomized

Effects of an HIV-Care-Program on Immunological Parameters in HIV-Positive Patients in Yaoundé, Cameroon; A Cluster Randomized Trial 

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BJGP – General Practice – Cluster Randomized

A Cluster Randomised Trial to Evaluate a Nutrition Training Programme

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Controlled Clinical Trials – Primary Care – Cluster Randomized

Mounting a Community-Randomized Trial: Sample Size, Matching, Selection, and Randomization Issues in PRISM

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Hepatology Research – Oncology/Genetic Screening – Agreement

Differential Methylation of the Promoter and First Exon of the RASSF1A Gene in Hepatocarcinogenesis

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Methods of Information in Medicine – Neurology/Radiology – Agreement

Automated Volumes-of-Interest Identification for Classical and Atypical Parkinsonian Syndrome Differentiation Using T2’ MR Imaging

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Thrombosis Research – Cardiology – Agreement

Intrinsic Platelet Reactivity and Thrombus Burden in Patients with ST-Elevation Myocardial Infarction

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Respiritory Research – Pulmonary – Higher Order Crossover

Indacaterol Provides 24-Hour Bronchodilation in COPD: A Placebo-Controlled Blinded Comparison with Tiotropium

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Urology – Radiology/Cardiology – Agreement

Computed Tomography Angiography and Perfusion to Assess Coronary Artery Stenosis Causing Perfusion Defects by Single Photon Emission Computed Tomography: The CORE320 Study 

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Urology – Urology/Oncology – Agreement

Prostate Specific Antigen/Solvent Interaction Analysis (PSA/SIA): A Preliminary Evaluation of a New Assay Concept for Detecting Prostate Cancer Using Urinary Samples  

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The Lancet – Radiology – Specificity

Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicenter study

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The Lancet – Radiology – Sensitivity

Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicenter study

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Clinical Therapeutics – Radiology – Higher Order Crossover

Bioavailability of Three Rufinamide Oral Suspensions Compared with the Marketed 400mg Table Formation: Results From a Randomized Sequence, Open-Label, Four-Period, Four -Sequence Crossover Study in Healthy Subjects

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CCLM – Radiology – Agreement

Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening

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CCLM – Clinical Chemistry – Agreement

Comparison of PR3-ANCA specific assay performance for the diagnosis of granulomatosis with polyangiitis (Wegener’s)

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ACTA – Anaesthesiology – Agreement

Double-blind comparison of the variability in spontaneous recovery of cisatracurium- and vecuronium-induced neuromuscular block in adult and elderly patients ...

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NEJM – Immunology – Cluster Randomised

A Cluster-Randomised Effectiveness Trial of Vi Typhoid Vaccine in India.

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Bristol Myers Squibb – Respiratory – Means

Cyclophosphamide versus Placebo in Scleroderma Lung Disease

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Baxter – Nephrology – Means

"Flush before fill" in children receiving automated peritoneal dialysis

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Baxter – Nephrology – Regression

Nephrology Dialysis Transplantation

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Bristol Myers Squibb – Cardiology – Means

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

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Zoetis – Veterinary – Proportions

Download this document which details an examples of sample size analysis found in the literature for Zoetis (formerly Pfizer Animal Health) Products replicated using nQuery + nTerim 3.0.  Bovine viral...

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Zoetis – Veterinary – Cluster Randomized

Evaluation of selective dry cow treatment following on-farm culture: Risk of postcalving intramammary infection and clinical mastitis in the subsequent lactation. Download this document which details an examples of...

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Amgen – Rheumatology – Proportions

Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis Year: 2013 Source: New England Journal of Medicine Clinical Area: Rheumatology ...

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Amgen – Oncology – Survival Analysis

A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer.  Year: 2009 Source: Journal of Clinical Oncology Clinical Area:...

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Sanofi – Neurology – Regression

Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomized, double-blind, placebo-controlled, phase 3 trial.  Year: 2014 Source: The Lancet Neurology Clinical Area: Neurology   ...

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Sanofi – Immunology – Means

Efficacy and safety of a modified killed- whole-cell oral cholera vaccine in India: an interim analysis of a cluster- randomized, double-blind, placebo- controlled trial.  Year: 2009 Source: The Lancet...

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Teva – Neurology – Means

This document details two examples of sample size analysis found in the literature for Teva Products replicated using nQuery + nTerim 3.0.Title: Three times weekly glatiramer acetate in relapsing–...

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Teva – Respiratory – Means

Title: Safety and efficacy of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with perennial allergic rhinitis Year: 2012 Source: Allergy and Asthma Proceedings  Clinical area: Respiratory ...

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Pfizer – Cardiology – Cluster Randomized

Download this document which details two examples of sample size analysis found in the literature for Pfizer Products replicated using nQuery + nTerim 3.0. Title: Proactive multiple cardiovascular risk...

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Pfizer – Cardiology – Survival Analysis

Download this document which details two examples of sample size analysis found in the literature for Pfizer Products replicated using nQuery + nTerim 3.0.  Title: Apixaban versus Warfarin in...

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Boston Scientific – Cardiology – Survival Analysis

Prospective comparison of discrimination algorithms to prevent inappropriate ICD therapy: Primary results of the Rhythm ID Going Head to Head Trial. Year: 2012 Source: Heart Rhythm Clinical Area: Cardiology ...

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Boston Scientific – Cardiology – Proportions

Quality of Life after PCI with Drug-Eluting Stents or Coronary-Artery Bypass Surgery Year: 2011 Source: The New England Journal of Medicine Clinical Area: Cardiology  ...

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Allergan – Urology – Means

Anticholinergic Therapy vs. OnabotulinumtoxinA for Urgency Urinary Incontinence  Year: 2012 Source: New England Journal of Medicine Clinical Area: Urology  ...

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Allergen – Urology – Means

Efficacy of Botulinum Toxin A Injection for Neurogenic Detrusor Over activity and Urinary Incontinence: A Randomized, Double-Blind Trial. Year: 2011 Source: New England Journal of Medicine Clinical Area: Urology ...

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Bayer Healthcare – Oncology – Survival Analysis

Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma.  This document details an example of sample size analysis found in the...

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Bayer Healthcare – Cardiology – Means

This document details an example of sample size analysis found in the literature for Bayer Healthcare products replicated using nQuery + nTerim 3.0.  Riociguat for the Treatment of Pulmonary...

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GlaxoSmithKline – Respiratory – Means

Sample size analysis for GlaxoSmithKline (Respiratory) This document details an example of sample size analysis for respiratory found in the literature for GlaxoSmithKline products replicated using nQuery + nTerim 3.0. ...

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GlaxoSmithKline – Respiratory – Means

Sample size analysis for GlaxoSmithKline This document details an example of sample size analysis found in the literature for GlaxoSmithKline products replicated using nQuery + nTerim 3.0.  Does a10-valent...

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Applied Example for Creating a Randomization List

Create a randomisation list with nQuery Advisor + nTerim Generating randomization strategies is an essential part of clinical trials. With nQuery Advisor + nTerim, creating randomization lists couldn't be easier,...

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Oncology – Survival Analysis

Applied Example for Oncology Studies with nQuery Advisor + nTerim Sample Size for survival analysis...

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Epidemiology – Confidence Interval

What sample size is required for an experiment to estimate an odds ratio with a confidence interval of specified width? This study plan is to evaluate an educational program for...

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Evaluation of SOLAS 2.0 for imputing missing values

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features_sample size tables2

Study Design Suite with over 370 Sample Size Tables

Sample size tables for over 370 different scenarios from fixed period, group sequential and cluster randomized trial designs.

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Customizable Plots

Easily conduct a variety of “What-If” scenarios to align your final sample size choice with your scientific and budgetary requirements.

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Customized Plot
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Standard Deviation and Effect Size

nQuery Advisor + nTerim provides you with the tools needed to estimate appropriate standard deviation and effect size.

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Intuitive Interface and Sample Size Statement

nQuery Advisor + nTerim has an easy to use interface to help you quickly and efficiently calculate sample size. The software automatically writes up your sample size statement in the correct language & format for submission to regulatory agencies and peer-reviewed publications.

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Intuitive Interface
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Customer Support

Personalized and friendly support from our statistical and technical team. Call us today.

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Randomization lists for basic, advanced and complex designs, generated in minutes.

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nQuery Advisor + nTerim

Software for Sample Size and Power Analysis

Accurately calculating power & sample size is crucial to establishing efficacy, leading to trial success at all stages of the clinical development process.

Introducing nQuery Advisor + nTerim, the most trusted, accurate, user friendly software for calculating power & sample size. nQuery Advisor + nTerim is favoured by top Pharma and Biotech companies, leading regulatory agencies and respected academic and research institutions worldwide. 

In fact, 85% of organizations with clinical trials approved in 2014, used nQuery Advisor + nTerim as their power analysis and sample size software. With nQuery Advisor + nTerim you too can:

With over 350 tables for fixed period, group sequential or cluster randomized designs, nQuery Advisor + nTerim is specifically designed to meet the needs and sample size software requirements of those working in the field of clinical trials and study design. 

 Try nQuery Advisor + nTerim Free Trial Here


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Learn how to Calculate Sample Size in 4 Easy Steps with our free guide.