Adaptive Clinical Trial Design Software

Adaptive trials can reduce the length of your trial by up to 30%

More efficient, informative & ethical trials

Reduce Trial Costs

Use adaptive designs like group sequential design to facilitate early interim decisions to ensure an efficient and ethical  conclusion to your trial.


Ensure Trial Success

Avoid under or overpowered trials by using sample size re-estimation to  adjust the sample size based on your blinded or unblinded interim results.

Design Complex Trials

Investigate multiple treatments and dynamically drop or add trial arms using multi-arm, multi-stage (MAMS) designs


Use nQuery Adapt to optimize your sample size for sophisticated adaptive clinical trials


Group Sequential Trials

Stop trials early using spending function, Wang-Tsiatis, Haybittle-Peto and more


Sample Size Re-estimation

Adjust sample size dynamically using promising zone or internal pilot designs


Multi-Arm Multi-Stage (MAMS)

Evaluate multiple treatments while dropping or adding study arms


Adaptive Phase IIa Designs

Reject unpromising treatments faster using methods such as Simon’s Design



Combine Phase IIa/IIb evaluations for superior evidence for Phase II trials 


Conditional Power

Find the probability of success at each interim analysis

Sample Size Platform for Adaptive Trials

From fixed to flexible designs, nQuery helps you confidentlyreduce the risk and cost of clinical trials

Frequently Asked Questions

[FPO] nQuery is used in Universities for teaching and research

What is nQuery Adapt?

How do I take a trial?

How do I purchase?

More about the Adaptive module in nQuery

Are Adaptive designs more efficient?

What is a Group Sequential Design?

What is sample size re-estimation (SSR)?

Conditional vs Predictive power?

Recommended Resources

Expert Insights

A Comprehensive Guide to Sample Size

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Trial Design Templates

Statistical & Therapeutic Examples

Trial Design Templates

Free Training

Designing Robust Group Sequential Trials

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Get started with nQuery today

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