What is unblinded sample size re-estimation?

An unblinded sample size re-estimation is done by increasing the sample size in response to an interim effect size that is ‘promising’. The uncertainty that you’re taking from the initial sample size determination will be around the effect size.

Recommended Viewing:
24.58s - Group Sequential Design | 30:10s - Unblinded Sample Size Re-estimation | 31:26s - Two Sample Mean Blinded SSR |
41:54s - Two Sample Binomial SSR