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An unblinded sample size re-estimation is done by increasing the sample size in response to an interim effect size that is ‘promising’. The uncertainty that you’re taking from the initial sample size determination will be around the effect size.
Recommended Viewing:
24.58s - Group Sequential Design
30:10s - Unblinded Sample Size Re-estimation
31:26s - Two Sample Mean Blinded SSR
41:54s - Two Sample Binomial SSR
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Download Blinded sample size re-estimation - Two sample mean sample data
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Download Blinded sample size re-estimation - Two sample binomial sample data
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