Unblinded Sample Size Re-estimation Template


What is unblinded sample size re-estimation?

An unblinded sample size re-estimation is done by increasing the sample size in response to an interim effect size that is ‘promising’. The uncertainty that you’re taking from the initial sample size determination will be around the effect size.

 

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24.58s - Group Sequential Design

30:10s - Unblinded Sample Size Re-estimation

31:26s Two Sample Mean Blinded SSR

41:54s Two Sample Binomial SSR

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